Work

Sex differences in exogenous glucose oxidation are attenuated by obesity: insights from a [U- 13 C 6 ]glucose home breath test

Year: 2026

Type: article

Abstract: ]glucose breath test during a 3-h OGTT, we show that normal-weight females oxidize a greater proportion of ingested glucose than males despite similar blood glucose and insulin responses. This sex difference is attenuated in obesity, which reduces overall glucose oxidation. These findings reveal sex-specific regulation of postprandial glucose metabolism not captured by conventional OGTT metrics and highlight breath testing as a sensitive, noninvasive approach for assessing glucose metabolism outside the laboratory.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00576.2025

Authors: Stephanie Estafanos, Daniel West, Anessa Koussiouris, Daniel R. Moore, Jenna B. Gillen

Institutions: University of Toronto, University Health Network

Language: English

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Natural Sciences and Engineering Research Council of Canada