Work

Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming

Year: 2026

Type: article

Abstract: Nuclear receptors are modular transcription factors regulated by ligands, chromatin context, and expression level. Wang et al. 2026, in this issue of Stem Cell Reports show that Rora controls OKS-mediated reprogramming in a dose-dependent manner: moderate expression enhances iPSC formation, while high levels inhibit it, linking quantitative Rora control to immune and WNT signaling during cell fate conversion.

Source: Stem Cell Reports

DOI: 10.1016/j.stemcr.2026.102871

Author: Constantinos Chronis

Institution: University of Illinois Chicago

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190