Diabetes secondary to chronic pancreatitis and pancreatic cancer: Observations from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Year: 2026
Type: article
Abstract: Diabetes secondary to diseases of the exocrine pancreas, including chronic pancreatitis (CP) and pancreatic cancer (PDAC), is easily confused with type 2 diabetes (T2D). Misdiagnosis as T2D is common due to poor understanding of the underlying pathophysiology of these diabetes subtypes. In this review, we highlight contributions from our research group to further characterize the distinctions between CP-DM and PDAC-DM as it relates to postprandial response to pancreatic polypeptide (PP) and key metabolic alterations compared to T2D. In general, the PP response is blunted, and there is relatively lower insulin secretion, higher insulin sensitivity, and alpha cell dysregulation in CP-DM and PDAC when compared to T2D. Additionally, we provide updates regarding ongoing work to use clinical and genetic data to model the prediction of incident CP-DM. Lastly, we identify remaining knowledge gaps to further improve the diagnosis and treatment of type 3c diabetes.
Source: Pancreatology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Mayo Clinic, Stanford University, Indiana University, Ohio State University, University of Minnesota, Baylor University, University of Florida, University of Pittsburgh, University of Texas at Austin, Cedars-Sinai Medical Center, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G155560493, G1617824425, G2793805583, G2912670434, G306811270, The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center, G619351912, G6972333521, G7171155687, G8327039090, G8421531598, Ohio Kentucky Pancreatitis Research Center (OKPRC) to advance the diagnosis and treatment of chronic pancreatitis, The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer
OpenAlex ID: W7148638743