Work

Long-Term Exposure to Ambient Air Pollution and Incident Amyotrophic Lateral Sclerosis

Year: 2026

Type: article

Abstract: BACKGROUND AND OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology. Although a range of genetic and lifestyle factors have been implicated, the potential role of environmental airborne pollution exposure is uncertain. This study examined the association between long-term ambient exposure to air pollutants and the incidence of ALS in UK Biobank participants. METHODS: genotype. RESULTS: for nonlinearity >0.05). These results remained robust in various subgroup and sensitivity analyses. No evidence of gene-environment interaction was found. DISCUSSION: In this large population-based study with high statistical power, ambient air pollution was not a risk factor for the development of ALS.

Source: Neurology

DOI: 10.1212/wnl.0000000000214858

Authors: Christos V. Chalitsios, Oliver Rudolf, Jiali Gao, Martin R. Turner, Alexander G. Thompson

Institution: University of Oxford

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute for Health and Care Research, Motor Neurone Disease Association, Medical Research Council