Work

Rh(III)-catalyzed C–H activation/annulation of fluoroalkylated benzhydrylamines with diarylalkynes enabled by amino directing groups

Year: 2026

Type: article

Abstract: Fluoroalkyl groups hinder C−H activation due to steric and electronic effects. This study develops N-based directing groups that enable Cp*Rh(III)-catalyzed C−H activation/annulation of fluoroalkylated benzhydrylamines with alkynes, giving fluoroalkylated dihydroisoquinolines—promising scaffolds for drug discovery.

Source: Tetrahedron Chem

DOI: 10.1016/j.tchem.2026.100160

Authors: Ryu Tadano, Takeshi Yasui, Yoshihiko Yamamoto

Institution: Nagoya University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,660

Funder: Japan Agency for Medical Research and Development