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There is No Role (yet) for Axillary Sentinel Lymph Node Biopsy in Inflammatory Breast Cancer

Year: 2026

Type: article

Abstract: Axillary staging has evolved from routine axillary dissection to sentinel node biopsy with selective omission of axillary staging for patients with early-stage, non-inflammatory breast cancer. For patients with inflammatory breast cancer, axillary dissection remains technically and oncologically necessary. However, studies have demonstrated a trend away from guideline concordant axillary surgery for patients with IBC without the literature to support it. Improved understanding of the biology and genetic drivers of the disease, systemic and locoregional therapies, and techniques may offer opportunities to de-escalate axillary surgery. This summarizes the history and role of axillary surgery in patients with IBC as of January 2026.

Source: Journal of Human and Clinical Genetics

DOI: 10.29245/2690-0009/2026/1.1312

Authors: Ashley D. Marumoto, Shirley Cheng, Naoto T. Ueno

Institutions: University of Hawaii Cancer Center, University of Hawaiʻi at Mānoa

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7148676711