Work

Aging alters synergistic microRNA networks in exosomes to stimulate repair in lung injury and skin wound healing

Year: 2026

Type: article

Abstract: experiments confirmed alterations in multiple downstream pathways, mediating reparative effects. These findings underscore age-dependent differences in stem cell-derived exosomes and demonstrate that synergistic miRNA cargo drives maximal efficacy.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2026.102927

Authors: Sharon J. Elliot, Sam Grimaldo, Paola Catanuto, Simone Pereira-Simon, Xiaomei Xia, Gina Civettini, Shahriar Shahzeidi, Irena Pastar, Marjana Tomic-Canic, Marilyn K. Glassberg

Institutions: Loyola University Chicago, University of Miami, University of Miami Health System, University of Arizona, University of Arizona College of Medicine- Phoenix

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Lester and Sue Smith Foundation, Loyola University Chicago Stritch School of Medicine

OpenAlex ID: W7148679449

FWCI: 1.872

Cites: 81

Cited by: 1

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