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How long should washout be to reliably measure hepatic de novo lipogenesis using deuterated water? Exploratory analysis from a randomized crossover trial

Year: 2026

Type: article

Abstract: Repeated deuterated water dosing in humans does not systematically bias measures of fasting hepatic DNL when using a washout duration of ∼4 wk. Fasting fractional hepatic DNL can be reliably assessed using deuterated water over sequential visits with as little as 3 wk washout between measures. At the group level, the within-participant variability in fasting hepatic DNL was relatively small and permits efficient detection of minimal clinically important differences in hepatic DNL with crossover studies.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00074.2026

Authors: Steven Carter, Louise Bradshaw, Bruno Spellanzon, Elspeth Johnson, Francoise Koumanov, Kaitlyn M. J. H. Dennis, Coco A. Taylor Start, Alfonso Moreno-Cabañas, Emma E. Vincent, Jennifer L. Maher, James A. Betts, Dylan Thompson, Leanne Hodson, Javier T. Gonzalez

Institutions: University of Bath, University of Oxford, University of Castilla-La Mancha, University of Bristol

Language: English

Topic: Lipid metabolism and biosynthesis

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: British Heart Foundation

Awards: Compartmentalisation of liver lipid flux determines atherogenic lipoprotein production and liver fat accumulation: the relevance of dietary macronutrient composition, Revealing the mechanisms by which milk sugars exaggerate postprandial lipaemia: implications for cardiovascular disease risk. ,

OpenAlex ID: W7148735809

FWCI:

Cites: 16

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