Work

Abstract 3046: Robust and durable antitumor activity of a novel PDE10 inhibitor, ADT-030, that enhances the efficacy of chemotherapy and immunotherapy by blocking RAS and β-catenin signaling and overcoming resistance to RAS-selective inhibitors

Year: 2026

Type: conference-abstract

Source: Cancer Research

DOI: 10.1158/1538-7445.am2026-3046

Authors: Gary A. Piazza, Dhana Sekhar Reddy Bandi, Veronica Ramirez Alcantara, Ganji Purnachandra Nagaraju, Junwei Wang, Sindhu Ramesh, Kristy Berry, Khalda Fadlalla, Elmar Nurmemmedov, Ivan Babic, Md Yeashin Gazi, Xi Chen, Jeremy B Foote, Adam B Keeton, Yulia Y. Maxuitenko, Donald Buchsbaum, Fokhrul Hossain, Gang Zhou, Bassel F. El-Rayes

Institutions: Auburn University, University of Alabama at Birmingham, University of South Alabama, Augusta University, Augusta University Health, Louisiana State University Health Sciences Center New Orleans

Language: English

Topic: Phosphodiesterase function and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7148807453

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