Work

Innovative Value of Amide Proton Transfer Imaging in the Diagnosis and Treatment of Brain Gliomas: From Basic Principles to Clinical Applications

Year: 2026

Type: article

Abstract: Conventional magnetic resonance imaging (MRI) exhibits notable limitations in the diagnosis, grading, and therapeutic assessment of gliomas, making it insufficient to meet the demands of precision medicine. As a chemical exchange saturation transfer MRI technique, amide proton transfer (APT) imaging enables molecular-level visualization by detecting the chemical exchange of amide protons in endogenous mobile proteins and peptides. Previous studies have demonstrated that APT imaging provides substantial advantages over conventional MRI in the diagnosis, grading, and treatment monitoring of gliomas. This review systematically summarizes the development of APT imaging technology, emphasizing its innovative clinical applications, including preoperative grading, differentiation of postoperative recurrence, and dynamic evaluation of radiotherapy and chemotherapy efficacy. Furthermore, it discusses current challenges and future directions for clinical implementation, aiming to offer new perspectives for advancing precision medicine in glioma management.

Source: Technology in Cancer Research & Treatment

DOI: 10.1177/15330338261441683

Authors: Changyue Yao, Weiguo Hu, Huali Liu, Zhihong Ran, Jingrui Hou, Qibin Song

Institutions: China Three Gorges University, Renmin Hospital of Wuhan University, First Affiliated Hospital of Guangzhou Medical University, Wuhan University

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650