Early-onset Refractory Neonatal Hypoglycaemia: An Unusual Presentation of Hypothalamic Hamartoma
Year: 2026
Type: article
Study design: Case Report
Abstract: Neonatal hypoglycaemia is a common metabolic emergency; however, persistent or refractory hypoglycaemia should prompt evaluation for endocrine and metabolic disorders. We report a case of a term female neonate with early-onset symptomatic hypoglycaemia found to be resistant to escalating glucose infusion rates and ultimately diagnosed with cortisol deficiency secondary to a hypothalamic hamartoma. Steroid therapy stabilised the blood glucose levels. This case underscores the importance of considering central endocrine causes in refractory neonatal hypoglycaemia and the role of neuroimaging in identifying rare aetiologies.
Source: Journal of Clinical Neonatology
Authors: Anjali Joshi, Jeetinder Joshi, P. Sriram
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7148977315