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Neffy: A latest needle-free epinephrine

Year: 2026

Type: article

Abstract: Anaphylaxis is a rapid-onset, potentially fatal allergic reaction requiring prompt administration of epinephrine. Until recently, epinephrine autoinjectors have dominated emergency treatment, but challenges, such as needle phobia, improper use, and poor carriage rates, reduce their real-world efficacy. Neffy (ARS-1; epinephrine nasal spray) introduces a needle-free, intranasal route for epinephrine delivery. This review examines the clinical evidence, pharmacological profile, indications, and safety data for Neffy and discusses implications for clinical practice.

Source: Saudi Journal of Anaesthesia

DOI: 10.4103/sja.sja_597_25

Authors: Konica Chittoria, Arun Mukesh, Ankur Sharma

Institutions: All India Institute of Medical Sciences Jodhpur, All India Institute of Medical Sciences, Kalyani

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7149024615

FWCI:

Cites: 15

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