Work

Development of a human multicellular engineered heart tissue

Year: 2026

Type: article

Abstract: Engineered heart tissue (EHT) is a 3D cardiac model made of hydrogel and cardiac cells cast in a mold anchored between two pillars. Since its introduction in 2002 (PMID: 11834716) it has become a key tool to reproduce the structure and function of native heart muscle in vitro. Developing multicellular EHTs (mEHTs) from human induced pluripotent stem cells (hiPSC)-derived cardiac cells provide a more physiological microenvironment, promoting cardiomyocyte (CM) maturation and generating tissues that better mimic the human myocardium (PMID: 35401829). This approach overcomes major limitations of current models, such as limited access to patient-derived CMs, low translational value of animal systems, and immaturity of 2D hiPSC-derived CMs.

Source: Open Research (University of Surrey)

Authors: Cavion, Federica, Frommelt, Laura Sophie, Colliva, A, Pramstaller, Peter P., Hicks, Andrew Anthony, Zacchigna, S, De Bortoli, Marzia

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7149228740

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