Work

The therapeutic potential of baicalin for stroke

Year: 2026

Type: article

Abstract: Despite rapid advances in modern medicine, stroke remains a life-threatening neurological emergency and a leading cause of death and disability worldwide. Stroke is broadly classified into ischemic stroke and hemorrhagic stroke, both of which trigger complex cascades of secondary brain injury. Pathological processes such as oxidative stress, neuroinflammation, blood–brain barrier disruption, cerebral edema, and delayed neuronal death are closely linked to poor long-term neurological outcomes, underscoring the urgent need for novel therapies. Baicalin, a natural flavonoid extracted from Scutellaria baicalensis , has demonstrated significant neuroprotective potential in preclinical studies. This review summarizes the pathophysiological basis of stroke and discusses the mechanisms by which baicalin may counteract disease progression. Particular emphasis is placed on the underlying mechanisms of its multi-target actions, pharmacokinetic characteristics, novel delivery strategies, and major barriers limiting its clinical translation. By integrating mechanistic and translational perspectives, this review provides a comprehensive evaluation of the therapeutic potential of baicalin in stroke management and highlights priorities for future clinical research.

Source: Brain Hemorrhages

DOI: 10.1016/j.hest.2026.04.001

Authors: Juan Xiong, Ping Zhang, Wei Mei

Institutions: Tongji Hospital, Huazhong University of Science and Technology

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Huazhong University of Science and Technology, Tongji Hospital