Work

An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model

Year: 2026

Type: article

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2026.04.009

Authors: Mattia Fumagalli, Dongjie An, Luca Simula, Camille Combe, Lisa Aziez, Yannick Simoni, Marie-Clotilde Alves-Guerra, Andrea Valentini, Maude Marchais, Anaïs Vermare, Josquin Moraly, Simona Manni, Maria Cecilia Quadraccia, Concetta Quintarelli, Biagio De Angelis, Nadège Bercovici, Emmanuel Donnadieu, Frédéric Pendino

Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, La Ligue Contre le Cancer, Institut Cochin, Technical University of Denmark, National Institutes of Health, National Cancer Institute, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, University of Naples Federico II

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Institut National de la Santé et de la Recherche Médicale, Ligue Contre le Cancer, China Scholarship Council, Université de Paris, Société Française d'Hématologie, Inserm Transfert, Institut Cochin

Award: G725035988

OpenAlex ID: W7149688173

FWCI: 16.45

Cites: 111

Cited by: 6

Related to: 10