Work

Rational Design of Dual-Target Molecules via a Fragment-Merging Strategy: TGR5 Agonism and SSTR5 Antagonism

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03308

Authors: Chuhua Song, Yu Wang, Xiaoyu Han, Mengya Li, Shimeng Guo, Lili Chen, Jun Sun, Fanghui Han, Yuqi Shi, Jing Hu, Jialin Zhao, Kai Wang, Xin Xie, Jianhua Shen

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, State Key Laboratory of Drug Research, Nanjing University of Chinese Medicine, Tongji University, ShanghaiTech University

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Youth Innovation Promotion Association of the Chinese Academy of Sciences, Taishan Scholar Project of Shandong Province

Awards: G1522379658, G2986465039, G6401848945, G6669830404

OpenAlex ID: W7150710019

FWCI: 3.69

Cites: 42

Cited by: 1

Related to: