I53-50: Engineered icosahedral protein cage for modular vaccine nanoplatform
Year: 2026
Type: article
Abstract: I53-50 is a computationally designed, self-assembling protein nanoparticle (NP) that forms a stable icosahedral structure composed of 120 protein subunits coordinated through precise interfacial interactions. Through unique intelligent regulation, I53-50 exhibits sensitivity to environmental signals and display multimodal "nano-smart" properties. I53-50 has a variety of modifiable surface-active sites, which facilitates precise chemical modification, gene fusion, tag coupling, and other functionalizations, thereby promoting effective lymphatic uptake and optimizing the immune response. I53-50 NPs show great potential in vaccine development, drug delivery, and biomaterials, representing a model fusion of computational biology and nanomedicine and offering a versatile tool for precision medicine.
Source: The Journal of Microbiology
DOI: 10.71150/jm.2511020
Authors: Ke Liang, Shuang Wu, Sihang Dong, Tao Xu, Hongtao Wang
Institution: Bengbu Medical College
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,690
OpenAlex ID: W7150721900