Work

Atrial electrophysiology in hypertrophic cardiomyopathy: current insights and knowledge gaps

Year: 2026

Type: article

Abstract: Hypertrophic cardiomyopathy is the most common inherited cardiac condition, associated with increased risks of heart failure, arrhythmias, and sudden cardiac death. Once considered a disease of the ventricular myocardium, growing evidence points towards atrial involvement, with structural and electrical atrial remodelling driven by a complex interplay of genetic, electrophysiological and hemodynamic factors. Despite advances in the understanding of this atrial substrate, management of atrial arrhythmias in hypertrophic cardiomyopathy remains challenging. Pharmacological therapies are limited by safety concerns, and catheter ablation shows lower efficacy in patients with hypertrophic cardiomyopathy compared to patients with structurally normal hearts. This review synthesizes current knowledge of disease related changes underlying atrial arrhythmias in hypertrophic cardiomyopathy and outlines diagnostic and therapeutic strategies. Particular emphasis is given to interventional treatment approaches, including emerging technologies and their evolving role in patients with hypertrophic cardiomyopathy.

Source: Journal of Interventional Cardiac Electrophysiology

DOI: 10.1007/s10840-026-02303-z

Authors: Magdalena Klis, Steven E. Williams, Mark O’Neill, Zohya Khalique

Institutions: King's College London, University of Edinburgh, Guy's and St Thomas' NHS Foundation Trust

Language: English

Topic: Cardiac Arrhythmias and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890