Work

Cutaneous lymphangiosarcoma in an African green monkey from St. Kitts, and a literature review

Year: 2026

Type: article

Abstract: ) with a pedunculated cutaneous ulcerated spheroid mass on the left flank was autopsied. Histologically, the mass was infiltrative, with neoplastic cells forming empty vascular channels lined by a monolayer of polygonal neoplastic cells, many with eosinophilic intracytoplasmic granules, supported by abundant fibrous stroma. Immunohistochemically, neoplastic cells had strong immunolabeling with vimentin, moderate immunolabeling with LYVE1 and PROX1 antibodies, and no cytokeratin or CD31 immunolabeling. Ultrastructurally, a basal lamina was absent, nuclei had a 1:4 heterochromatin:euchromatin ratio, with a mild-to-moderate increase in thickness and asymmetrically distributed nuclear fibrous lamina, enlarged compacted nucleolus, round mitochondria, conspicuous rough endoplasmic reticulum, and membrane-bound electron-dense granules. Intercellular desmosomes were present in clusters of neoplastic cells. Lymphangiosarcoma has not been previously reported in non-human primates, to our knowledge. Our case highlights the importance of integrating histopathology, immunohistochemistry, and ultrastructural analysis to accurately diagnose rare vascular tumors, such as lymphangiosarcoma.

Source: Journal of Veterinary Diagnostic Investigation

DOI: 10.1177/10406387261436421

Authors: Diana Bochynska, Anibal Armien, Macallister Harris, Andrew Curtis, Pompei Bolfa

Institutions: University of California, Davis, Colorado State University, Ross University School of Veterinary Medicine

Language: English

Topic: Veterinary Oncology Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7151091109