Work

Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, In Vitro Screening, and In Vivo Evaluation in Nonhuman Primates

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03014

Authors: Jiwei Gu, Chao Wang, Luca Gobbi, Michael Honer, Ming-Qiang Zheng, Paul Gravel, Hong Gao, Li Zhang, Jim Ropchan, Nabeel Nabulsi, Edilio Borroni, Gilles Tamagnan, Richard Carson, Yiyun Huang

Institutions: Yale University, Roche (Switzerland)

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Institutes of Health

Award: G9000172764

OpenAlex ID: W7151237153

FWCI:

Cites: 46

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