Work

Inducible POU Class 2 Homeobox 3 Expression in Human Intestinal Organoids as a Model of Human Tuft Cells

Year: 2026

Type: article

Abstract: Tuft cells, name for their tufts of apical microvilli, are relatively drare chemosensory cells found in the epithelium of several organs, dincluding lungs, stomach, intestine, and pancreatic duct. They express genes canonically associated with taste signaling such as CHAT, TRPM5, and POU Class 2 Homeobox 3 (POU2F3).1 POU2F3 plays a role in cell fate specification of tuft cells and is essential for tuft cell differentiation.2 Characterization of human tuft cells has remained difficult due to their rarity in vivo and the lack of in vitro models.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2026.101784

Authors: Carolyn Bomidi, Luqiong Wang, Hoa Nguyen-Phuc, Mary K. Estes, Sarah E. Blutt

Institution: Baylor College of Medicine

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,430

Funder: National Institute of Allergy and Infectious Diseases