Plasma membranes: does one model fit all?
Year: 2026
Type: review
Abstract: Biological membranes consist of a lipid bilayer with a highly asymmetric distribution of lipids in the two leaflets. This asymmetry is maintained by enzymes whose activities depend on cytosolic ATP and Ca 2+ concentrations. Recently, a new model for plasma membranes (PMs) was introduced. It is based on studies with human erythrocytes and suggests that there is a 50% overabundance of lipids with two hydrophobic chains in the cytosolic leaflet, compensated by the presence of three times more cholesterol in the outer leaflet. In this opinion article, we discuss the large differences in lipid composition between erythrocytes and other cell types, the assumptions used to reach the new membrane model, and whether this model would fit PMs of other cell types.
Source: Trends in Cell Biology
Authors: Tore Skotland, Kirsten Sandvig
Institutions: Oslo University Hospital, University of Oslo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
OpenAlex ID: W7151797014