Work

Prospective, Randomized, Double‐Blind, Placebo‐Controlled Study of an Oral Antioxidant‐Rich Synbiotic Supplement on Skin Health and Photoaging

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: Photoaged skin is primarily induced by prolonged exposure to ultraviolet radiation, leading to increased pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of the influence of nutrition on skin health, with dietary elements emerging as a viable alternative approach to preventing photoaging. This study explores how oral supplementation impacts photoaged skin, hydration, and elasticity. AIMS: This study evaluates the effects of an antioxidant-rich synbiotic supplement on facial elasticity, hydration, and photoaging markers, such as erythema and pigmentation. PATIENTS/METHODS: In this 8-week study, 36 participants from the Sacramento region were randomized to receive either the antioxidant-rich synbiotic supplement or a placebo. Participants had 3 visits: baseline, week 4, and week 8. Noninvasive facial measurements, including hydration, elasticity, erythema, and pigmentation, were obtained. Facial photography and analysis were performed. Tolerability was assessed. RESULTS: At week 8, the treatment group showed a significant reduction in wrinkle severity (-5.28%, p < 0.01), whereas the placebo group did not. Cheek elasticity increased significantly at week 4 (22.0%, p < 0.01) and week 8 (13.8%, p < 0.05), along with firmness at week 8 (12.2%, p < 0.01). The placebo group showed no significant changes in these parameters. Additionally, the viscoelasticity of the cheek increased at week 4 (30.2%, p < 0.01) in the treatment group, with no change in the placebo group. CONCLUSIONS: The antioxidant-rich synbiotic supplement improved wrinkle severity, skin facial elasticity, and skin firmness, enhancing several parameters of photoaging.

Source: Journal of Cosmetic Dermatology

DOI: 10.1111/jocd.70836