Colonic Histoplasma capsulatum Infection Simulating a Polypoid Lesion: Reactivation of a Long-Dormant Disease in a Patient With Chronic Renal Failure
Year: 2026
Type: article
Study design: Case Report
Abstract: A 73-year-old Japanese man undergoing hemodialysis for chronic renal failure, with a history of sigmoid colon low-grade adenoma, underwent follow-up colonoscopy. A 5 mm rectal polypoid lesion was identified and resected by endoscopic mucosal resection. Histopathological examination revealed granulomas and clusters of histiocytes containing intracytoplasmic yeast-like organisms. Polymerase chain reaction analysis of paraffin-embedded tissue identified the genome of Histoplasma capsulatum . The patient had visited Brazil 30 years earlier, where he was presumed to have acquired the infection without developing clinical disease. Following the onset of immunocompromised status associated with long-term hemodialysis, the previously latent H. capsulatum infection appeared to have reactivated.
Source: ACG Case Reports Journal
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7152059700