Work

Tailored analytical strategies for AAV aggregation: purpose‑driven method selection for enhanced product development

Year: 2026

Type: article

Abstract: No single analytical method captures all AAV aggregation species across all conditions. A purpose-driven framework for selecting SEC-UV, SEC-FLD, DLS, and A4F – what each method detects, where each fails, and how to combine them for release testing, stability studies, and forced degradation.

Source: Cell and Gene Therapy Insights

DOI: 10.18609/cgti.2026.029

Authors: Yan Zhao, Lin Wang, John S Reeves, Wen Shi, Nina Liu, Yan Yu, Lin Luo, Polat Abdubek, Glynn O’Grady, Aishwarya Shevade, Yuan Cao, Serena Wang, Michael Rosconi, Kenneth Graham, Dingjiang Liu, Mohammed Shameem, Andrew D Tustian

Institution: Regeneron (United States)

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7152482576

FWCI:

Cites:

Cited by:

Related to: