Ferroptosis as an approach to leverage cancer metabolism
Year: 2026
Type: review
Abstract: Ferroptosis is a cell death process defined by the iron-mediated peroxidation of membrane phospholipids that overwhelms the cell's innate antioxidant capabilities. Sitting at the nexus of iron, lipid, reactive oxygen species stress responses, and cellular metabolism, ferroptosis is intricately tied to these pathways. The burgeoning field of cancer metabolism has revealed that cancer cells exhibit changes in ferroptosis-relevant metabolic pathways, thereby opening an important avenue of investigation into whether tumors can have characteristic metabolic alterations that render them exquisitely sensitive to ferroptotic cell death. In this review, we highlight recent findings in the metabolic pathways linking ferroptosis and oncogenesis, as well as implications for future cancer therapeutic strategies.
Source: Trends in Cell Biology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Funders: U.S. Department of Defense, American Lung Association, Columbia University, Memorial Sloan-Kettering Cancer Center, Commonwealth Foundation for Cancer Research Foundation, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Congressionally Directed Medical Research Programs
Awards: G2051006376, G289723095, G3564729904, G3994034673, G4102770861, G613936551, Cancer Center Support Grant, Ferroptosis and Cancer Cell Signaling, p53-mediated metabolic regulation in tumor suppression, Co-regulation of p53 and PD-L1 by the VPRBP-USP2 axis in transcription and ubiquitylation, Lipid Metabolism as a Determinant of Ferroptosis Sensitivity in Cancer, Ferroptosis, Cellular Metabolism, and Cancer, Cancer Center Support Grant, The Columbia University Digestive and Liver Disease Research Center, Mutant p53 in Tumorigenesis, Invasion, and Metastasis, G94832637
OpenAlex ID: W7152593063