A New Methoxyflavonoid Rutinoside and PTP1B-Inhibitory Phenolic Compounds from the Water Extract of Areca catechu L.
Year: 2026
Type: article
Abstract: Phytochemical investigation of the water extract and alkaloid fraction of Areca catechu L. led to the isolation of one new methoxyflavonoid rutinoside (1), together with eleven known compounds (2−12), five of which (8−12) belong to the pyridine alkaloid class. The structure of the new compound was elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and high-resolution mass spectrometry. Notably, rhamnazin-3-O-rutinoside (2) is reported here for the first time from this species. The isolated compounds were evaluated for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using a p-nitrophenyl phosphate assay. Flavonoids (3 and 4) and stilbene (5) exhibited notable inhibitory activity, with IC50 values of 13.30 ± 0.71, 13.44 ± 0.84, and 8.68 ± 0.12 μM, respectively. In contrast, methoxyflavonoid rutinosides (1 and 2) and pyridine alkaloids (8−12) did not show significant inhibitory activity against PTP1B. These findings provide additional chemical insights into A. catechu and its constituents in relation to PTP1B inhibition.
Source: Natural Product Sciences
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
Funder: Ministry of Food and Drug Safety
Award: G1382729119
OpenAlex ID: W7152675142