Work

Direct assessment of total cavopulmonary connection power loss with interventional cardiac magnetic resonance in Fontan circulation

Year: 2026

Type: article

Abstract: ABSTRACT Background Fontan physiology, reliant on a single ventricle and a passive total cavopulmonary connection (TCPC) flow, is vulnerable to inefficiency. Linking TCPC power loss to cardiac function can provide valuable insights into Fontan hemodynamics. This study quantifies direct TCPC power loss from invasive cardiovascular magnetic resonance (iCMR) data and its relationship to conduit geometry, fenestration flow, and myocardial contractility pre- and post-Fontan fenestration test occlusion (FFTO). Methods Twenty post-Fontan patients underwent iCMR, with 9 also having a FFTO. iCMR catheter-based pressures were combined with phase-contrast CMR flow in the vena cavae and pulmonary arteries. Three-dimensional (3D) whole-heart imaging provided conduit cross-sectional areas (CSA). A patient-specific biomechanical model estimated myocardial contractility from iCMR data. In-vivo TCPC blood flow indexed power loss ( iPL ) was calculated at baseline in 20 patients, and post-FFTO in 9. Results Mean (±SD) at baseline was 0.24 ± 0.15 and decreased significantly from 0.27 ± 0.14 to 0.13 ± 0.10 in 9 patients post-FFTO (p = 0.010). Fenestration flow explained 46.5% of variation in iPL at baseline. Higher iPL was associated with higher myocardial contractility (R 2 = 0.216, p = 0.004) pre-FFTO, and with lower myocardial contractility (R 2 = 0.43, p = 0.054) post-FFTO. Higher iPL correlated with smaller conduit CSA (R 2 = 0.26, p = 0.030) at baseline. Conclusion Increased iPL was related to increased fenestration flow, increased contractility, and decreased conduit narrowing at baseline. Post-FFTO, increased iPL was associated with decreased contractility, suggesting that acute fenestration closure might cause preload suppression in the ventricle. This study offers a clinically relevant framework to obtain mechanistic insights into Fontan physiology and guide personalized strategies for fenestration management.

Source: Journal of Cardiovascular Magnetic Resonance

DOI: 10.1016/j.jocmr.2026.102724

Authors: Hamza Dahshi, Tarique Hussain, Surendranath Veeram Reddy, Yousef Arar, Maria Gusseva

Institutions: Case Western Reserve University, The University of Texas Southwestern Medical Center

Language: English

Topic: Congenital Heart Disease Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000