Year: 2026
Type: article
Abstract: The aim of the work. To carry out the synthesis of a series of functionally substituted anthraquinone derivatives, to investigate their antimicrobial activity, and to predict the drug-likeness of the obtained compounds using modern web-based tools. Materials and methods. Standard methods of organic synthesis were employed, and physicochemical characterization of the synthesized compounds was performed. The antimicrobial activity was evaluated using the agar diffusion method and the serial dilution method in accordance with generally accepted microbiological protocols. In silico drug-likeness screening of the synthesized compounds was carried out using the SwissADME online service. Results and discussion. A series of new functionally substituted anthraquinone derivatives was synthesized. Based on the results of antimicrobial activity screening, compound 5 was identified as the hit compound, exhibiting the highest level of activity among the tested compounds. It was found that other anthracenedione derivatives do not exhibit pronounced antimicrobial and fungistatic activity, which may be due to the peculiarities of their chemical structure. The results obtained indicate the prospects for further research into anthracenedione derivatives as potential antimicrobial agents. Conclusions. A series of four functionally substituted anthraquinone derivatives was synthesized and their antimicrobial activity was evaluated. Compound 5 was found to exhibit antimicrobial activity against Gram-positive microorganisms, whereas the other tested compounds showed no detectable activity under the same conditions. In silico prediction of drug-likeness and potential toxicity for compound 5 using modern web-based tools indicated favorable pharmacokinetic properties and no obvious signs of toxicity. These results highlight the potential of functionally substituted anthraquinone derivatives for further investigation as prospective antimicrobial agents.
Source: Фармацевтичний часопис
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7153204989