Work

Delayed Postoperative Wound Healing during Alectinib Therapy for Poorly Differentiated Lung Adenocarcinoma: A Case Report

Year: 2026

Type: article

Abstract: Introduction: Anaplastic lymphoma kinase (ALK) rearrangement is a key oncogenic driver in non-small cell lung cancer. Alectinib, a highly selective second-generation ALK inhibitor, has demonstrated remarkable clinical efficacy; however, its potential influence on postoperative wound healing remains unclear. Case Presentation: We report the case of a 42-year-old male with ALK-positive poorly differentiated lung adenocarcinoma who underwent right lower lobectomy following significant tumor regression with alectinib therapy. Postoperatively, the patient developed delayed wound healing complicated by Staphylococcus aureus infection. After temporary discontinuation of alectinib combined with repeated debridement, negative pressure wound therapy, and wound closure, the lesion achieved complete healing. Conclusion: This case highlights the possibility that alectinib may impair postoperative wound repair. Comprehensive perioperative drug evaluation, multidisciplinary collaboration, and carefully monitored treatment interruption are recommended to maintain the balance between oncologic control and effective tissue healing.

Source: Case Reports in Oncology

DOI: 10.1159/000551911

Authors: Yanhua He, Gongdan Xu, Xue Yang, Lu Li, Mingying Tan

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,170