Work

Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen‐Bonded Pairs and Aromatic Components in Palladium(II)‐Based Interlocked and Foldameric Systems

Year: 2026

Type: article

Abstract: ABSTRACT Nature's exquisite control over structure arises from its use of complex arrays of topologically complicated species capable of forming and functioning orthogonally. Chemists seek the same level of control in synthetic systems, and here we report the design rules for self‐assembly of systems integrating metal‐coordination to Pd(II), complementary geometries, interligand hydrogen bonding, and π─π interactions. This has been achieved by integrating hydrogen‐bonded complementary pairs, AA:DD and DA:AD ( A = acceptor, D = donor), and complementary aromatic regions of high and low electron density into a series of ligands which controllably self‐assemble into defined three‐dimensional structures with Pd(II). These rules have allowed us to elucidate pathways to multiple molecular types with defined connectivity and topology, including metallo‐foldamers, cyclic species, and an interlocked clippane formed under thermodynamic control. We have also established that, despite similarities between their respective components, these diverse structures persist in a combinatorial mixture.

Source: Angewandte Chemie

DOI: 10.1002/ange.5763518

Authors: Jess L. Algar, Jordan N. Smith, Dan Preston

Institution: Australian National University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funders: Australian National University, Australian Research Council