Natural smart hydrogels for osteoporosis therapy: Dynamic sensing, targeted delivery, and bone remodeling
Year: 2026
Type: article
Abstract: Osteoporosis is a prevalent bone metabolic disorder globally, constituting a significant public health concern. Traditional therapeutic approaches, such as calcium supplementation and anti-resorptive medications, frequently exhibit limited absorption, adverse side effects, and inadequate regulation of bone remodeling processes. In recent developments, natural smart hydrogels have emerged as promising next-generation therapeutic options for osteoporosis. These materials possess the ability to emulate the bone microenvironment, detect pathological alterations, and deliver therapeutic agents with precision. This review provides a comprehensive overview of the recent advancements in the application of natural smart hydrogels for osteoporosis treatment, with an emphasis on their dynamic sensing mechanisms, targeted delivery systems, and contributions to bone remodeling. Furthermore, we address critical challenges, including the synchronization of degradation with regeneration, optimization of multi-factor release, and enhancement of clinical translation. Finally, we propose prospective directions centered on programmable design and intelligent feedback regulation to facilitate personalized and adaptive treatment strategies. This review aims to offer novel insights into the development of intelligent biomaterials for precision bone regeneration.
Source: Polymer Testing
Authors: Zhe Sui, Haoxuan Li, Yuhang Zhu, Mengchao Zhang, Yihang Ma
Institution: Jilin University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,370
OpenAlex ID: W7153765729