Work

Confined coordination regulation of rhodium in organosilica active framework for enhanced photothermal-enzymatic diabetic wound healing

Year: 2026

Type: article

Abstract: The modulation and alteration of metal coordination structure is intricately associated with their biological activity. However, the precise control of metal active site in a matrix and thereby enhance the biological activity remains a great challenge. Herein, a convenient “ reduction-mediated coordination regulation ” strategy was proposed to construct novel rhodium-oxygen clusters in confined organosilica active framework ([RhO 3 ] NC -FOMs) with enhanced photothermal-enzymatic properties for efficient and safe diabetic wound healing. Results revealed that coordination structure of Rh in organosilica-based matrix can be easily adjusted from [RhS 2 ] NC -FOMs to [RhO 3 ] NC -FOMs by changing the reactive conditions from neutral to reductive environment. Simultaneously, the confined effect in physical space ensured uniform and stable [RhO 3 ] coordination structure. Compared with [RhS 2 ] NC -FOMs and other reported Rh-based materials, [RhO 3 ] NC -FOMs demonstrated superior photothermal conversion efficiency exceeding 80% under 808 nm laser, along with remarkable POD/CAT/SOD-like multi-enzymatic activities, thereby enhancing infected diabetic wound healing. This work provides a simple and effective strategy to regulate metal coordination structure for promising therapeutic applications.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2026.103109