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Beyond existence: Physiologic phenotyping of patent foramen ovale

Year: 2026

Type: article

Abstract: Patent foramen ovale (PFO) closure has matured from an anatomic procedure in search of an indication to a guideline-supported therapy for carefully selected adults with PFO-associated ischemic stroke [1].A PFO is common and stroke is common; however, their coexistence is often incidental.Paradoxical embolism requires 3 elements: an upstream venous milieu capable of generating embolic material, a conduit that permits right-to-left vascular passage, and a downstream systemic vascular bed vulnerable to occlusion [2].Without actual right-to-left shunting, venous material cannot plausibly reach the arterial circulation.This mechanistic truth

Source: Kardiologia Polska

DOI: 10.33963/v.phj.112122

Authors: Ashish H Shah, Richard A Krasuski

Institutions: University of Manitoba, Duke University, Duke Medical Center, Duke University Health System

Language: English

Topic: Cardiovascular and Diving-Related Complications

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7153972108

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