Work

Modulation of oxidative stress and P53/PCNA signaling by glucosodiene-loaded nanoferrites (GLONF) in ehrlich solid tumor–induced hepatotoxicity

Year: 2026

Type: article

Abstract: Ehrlich solid tumors are commonly used as a model to study tumor growth and evaluate potential anticancer therapies. Current study aimed to assess the curative efficacy of glucosodiene Loaded over Nanoferrites (GLONF) against Ehrlich solid tumor (EST) induced hepatotoxicity. Fifty female mice were randomly allocated into five equal groups (Control; GLONF; EST; GLONF + EST; EST+GLONF). Our findings revealed that the EST group exhibited significantly increased levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), hepatic injury indices, malondialdehyde (MDA), proliferating cell nuclear antigen (PCNA), and apoptotic p53, while showing significant depletion of albumin, total proteins, catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) when compared to the control group. GLONF post-treatment (EST+ GLONF) is a highly effective strategy, demonstrating potent antitumor where it reduced tumor size, hepatoprotective, and antioxidant actions, restoring liver integrity, modulating key molecular markers and improving histological and immunohistochemical profiles.

Source: Scientific Reports

DOI: 10.1038/s41598-026-45548-4

Authors: Ehab Tousson, Afaf El Atrash, Mariam Y. Abdelrasol, Amina I. Ghoneim

Institution: Tanta University

Language: English

Topic: Cancer and biochemical research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690