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Stromal Vascular Fraction Across Different Clinical Indications: A Pro-Regenerative Fil Rouge

Year: 2026

Type: article

Abstract: Stromal vascular fraction (SVF) has emerged as a versatile autologous therapeutic strategy across multiple regenerative medicine applications. Derived from adipose tissue, SVF exerts its effects primarily through paracrine, immunomodulatory, pro-angiogenic, and anti-fibrotic mechanisms rather than direct cell differentiation. Potential regenerative outcomes have been reported in bone, cartilage, scar modulation, and neural repair, highlighting a shared pro-regenerative cascade centered on early inflammation control and vascular support. Indeed, increasing evidence suggests that synergy with biomaterials and point-of-care one-step approaches further enhances SVF efficacy. Regarding the real clinical potential, however, transability is still limited due to heterogeneity in isolation methods, lack of standardization, and insufficient large-scale randomized controlled trials.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm15082937

Authors: Giuseppe Perale, Daniel Schmauss

Institutions: Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Università della Svizzera italiana, Ospedale regionale di Lugano, Ente Ospedaliero Cantonale

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137