Work

Pathogenesis and kidney prognosis of renal amyloidosis

Year: 2026

Type: article

Abstract: Light chain (AL), serum amyloid A (AA), transthyretin (ATTR), leukocyte cell derived chemotaxin 2 (ALECT2), and fibrinogen Aa (AFib) amyloidosis are some of the most common types of protein-deposition disorders involving the kidney. Each amyloidogenic protein differs in its origin and little is known about the exact mechanisms that govern renal tropism and tissue injury for each amyloid subtype. While amyloidogenic precursor protein is different in each subtype of amyloidosis, its aggregation into fibrils depositing in target organs and leading to disruption of tissue architecture and progressive organ failure is a common denominator. Each amyloidogenic protein is characterized by a unique pattern of deposition in the renal parenchyma with variability in expected clinical outcomes. In this review, we focus on describing the distinct pathophysiologic mechanisms at the level of the kidneys of AL, AA, ATTR, ALECT2, and AFib amyloidosis.

Source: Cellular and Molecular Life Sciences

DOI: 10.1007/s00018-025-06030-y

Authors: Alvin Hu, Raad B. Chowdhury, Giada Bianchi

Institutions: Brigham and Women's Hospital, Massachusetts General Hospital, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,290