Work

Cross-species transmission of blaNDM-5-IncX3 plasmids: molecular mechanisms and One Health-based strategies for CREC control

Year: 2026

Type: article

Abstract: Carbapenem-resistant Escherichia coli (CREC) has emerged as a critical global health concern, particularly strains carrying the bla NDM-5 -IncX3 plasmid. In this review, we synthesize recent advances in the molecular epidemiology, resistance mechanisms especially the transmission dynamics of the bla NDM-5 -IncX3 plasmid, virulence factors, research methodologies, and current strategies for the prevention and control of CREC. We further explore the cross-species dissemination and adaptive evolution of bla NDM-5 -IncX3 plasmids within the interconnected human-animal-environment interface. Based on these insights, we propose a novel triadic transmission model—”structural adaptation, host reciprocity, and environmental driving”, alongside a One Health-based, multidimensional intervention framework spanning clinical, agricultural, and environmental domains. This review provides critical perspectives for the containment of carbapenem-resistant Enterobacteriaceae , offers theoretical support for anti-infective clinical practice, informs evidence-based public health policy, and facilitates the implementation of the One Health approach in antimicrobial resistance (AMR) governance.

Source: Frontiers in Cellular and Infection Microbiology

DOI: 10.3389/fcimb.2026.1783836

Authors: Benjin Xu, Ling Liu, Hui Fu, Meicheng Liu, Xiaoyan Li

Institutions: Shanxi Medical University, Shanxi Fenyang Hospital, Shanxi University of Medicine

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801