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Refining Glial Fibrillary Acidic Protein Diagnostics for Prehospital Stroke Triage

Year: 2026

Type: article

Abstract: When stroke is suspected in the prehospital setting, the ability to rule out intracranial hemorrhage (ICrH) in all ambulances would guide triage decisions, steer early management of hemodynamics, and help prepare the receiving hospital. In this prospective observational study, we investigated the diagnostic performance of plasma glial fibrillary acidic protein (GFAP) for ultra-early rule-out of ICrH in acute cerebral ischemia (ACI) and stroke mimic (SM) patients in a large, unselected stroke-code patient cohort.

Source: Neurology Open Access

DOI: 10.1212/wn9.0000000000000088

Authors: Olli S. Mattila, Markku Kuisma, Saana Pihlasviita, Tiina Nukarinen, Heini Harve-Rytsälä, Juhani Ritvonen, Gerli Sibolt, Sami Curtze, Daniel Strbian, Mikko Pystynen, Turgut Tatlisumak, Perttu J. Lindsberg

Institutions: University of Helsinki, Helsinki University Hospital, University of Gothenburg

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7154059859

FWCI:

Cites: 19

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