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Anti‐ p200 Pemphigoid in an Infant Clinically Mimicking Linear IgA Disease

Year: 2026

Type: article

Abstract: We report a 10-month-old boy with annular/polycyclic vesicles on his face, neck, trunk, and extremities that clinically and histomorphologically indicated linear IgA disease (LAD)/chronic bullous disease of childhood (CBDC); however, the immunofluorescence findings and serum positivity for anti-laminin β4 antibodies were consistent with anti-p200 pemphigoid. His condition improved with prednisolone but recurred during tapering; remission was achieved following dapsone administration. Anti-p200 pemphigoid often resembles bullous pemphigoid clinically and is characterized similarly by subepidermal bullae with linear IgG antibody reactivity and C3 basement membrane zone (BMZ) localization, but differs in its target antigen.

Source: Pediatric Dermatology

DOI: 10.1111/pde.70212

Authors: Elek A. Wellman, Joseph D. Conlon, Kristin M. Leiferman, Morgan L. Wilson

Institutions: SIU Medicine, Springfield Clinic, University of Utah, ARUP Laboratories (United States)

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7154065540

FWCI:

Cites: 6

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