Osteogenic, antiresorptive, and toxicological evaluation of alpha-mangostin in MC3T3-E1 cells and medaka fish
Year: 2026
Type: article
Abstract: values (concentrations causing 50% of developmental abnormalities) of 103.66 and 3.3 μM, respectively, leading to tail deformities, hemorrhage, and reduced hatching and heart rates. At sub-toxic concentrations (0.25-1 μM), aMG significantly attenuated Rankl-induced bone loss in the neural arches of osteoporotic medaka larvae. Collectively, this study provides the first evidence of the dual osteogenic and antiresorptive actions of aMG, along with its toxicity profile, highlighting its potential as a plant-derived anti-osteoporosis agent.
DOI: 10.4196/kjpp.25.370
Authors: Ut Dong Thach, Huy Manh Nguyen, Van Oanh Nguyen, Chau Phi Dinh, Thi Thuy Trang Le, Thi Ngoc Tram Le, Ngoc Mai Do, Thi Nhung Duong, Thi Bich Pham, Duc Long Tran, Thanh Thuy To
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
Award: G61863109
OpenAlex ID: W7154078079