Pyrroloquinoline quinone scaffolds: centrality in anticancer drug design
Year: 2026
Type: article
Abstract: The Pyrroloquinoline Quinone (PQQ) is a quinone molecule that is redox active and has important health consequences for people. Several preclinical studies reveal the anticancer property of PQQ molecule by different molecular pathways. but there is a lack of clinical studies evaluating this drug in oncology. Clinical investigations have only investigated PQQ as a dietary supplement, disodium salt. The known safety profile and availability of standardized formulations provide the opportunity to advance PQQ into translational research in cancer. Future initiatives will involve testing in animal tumor models, analyzing possible synergistic effects with existing medicines, improving formulations to boost absorption, and discovering biomarkers to help patient selection.
Source: Future Medicinal Chemistry
Authors: Siuli Sen, Dipanjan Karati
Institution: Techno India University
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7154116726