Innovative Biomaterials for Modulating Neuroinflammation and Promoting Repair After Traumatic Brain Injury
Year: 2026
Type: article
Abstract: Traumatic brain injury (TBI) represents a significant global health challenge with limited effective treatments. The secondary injury phase, characterized by persistent neuroinflammation, is a major contributor to long-term neurological deficits. Conventional therapies face substantial hurdles, including the blood-brain barrier (BBB), short therapeutic windows, and poor neuroregenerative capacity. Innovative biomaterials offer a promising platform to overcome these limitations by providing localized Drug Deliv., immunomodulation, and structural support for neural regeneration. This review outlines the pathological mechanisms of neuroinflammation and repair obstacles following TBI. It then systematically categorizes and discusses the mechanisms of various biomaterials-including natural, synthetic, nano-scale, composite, and intelligent materials-in modulating neuroinflammation. Furthermore, we elaborate on strategies for promoting neural repair, such as constructing regenerative scaffolds, delivering therapeutic agents (e.g., neurotrophic factors, stem cells, and exosomes), and remodeling the regenerative microenvironment. Special emphasis is placed on the emerging application of exosome delivery systems. Finally, we address the challenges in clinical translation and present future perspectives on smart materials, multi-modal systems, and personalized therapies, highlighting the transformative potential of biomaterials in TBI management.
Source: Pharmaceutics
Authors: Ziwei Wang, Wenlong Yuan, Jin Li, Meng Qin
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Award: G8608487350
OpenAlex ID: W7154123181