Work

Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

Year: 2026

Type: article

Abstract: We developed a green and efficient method for Pd‐catalyzed N‐arylation of ortho‐acylanilines in water using rhamnolipid‐based micellar catalysis. The (cinnamylPdCl) 2 / t BuXPhos system enables high yields at 40°C, significantly lower than conventional methods (>100°C), with broad substrate scope. This industrially produced biodegradable surfactant system offers a sustainable alternative to organic solvents, combining enhanced reactivity with improved energy efficiency and environmental compatibility.

Source: ChemSusChem

DOI: 10.1002/cssc.70609

Authors: Attila R. Herczegh, Péter R. Kollár, Johannes Lehmann, Zoltán Novák

Institutions: Eötvös Loránd University, Evonik (Germany)

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $4,550