Work

Atypical Response Patterns and Immune-related Adverse Events Detected by FDG PET/CT in Patients Receiving Immunotherapy: A Case Series and Literature Review

Year: 2026

Type: article

Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet their efficacy assessments using conventional imaging remain challenging due to atypical response patterns and immune-related adverse events (irAEs). We present a case series of five patients who underwent different immunotherapies for various solid cancers and were evaluated with 18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT), highlighting pseudoprogression, dissociated responses, sarcoid-like reactions, and immune-mediated pancreatitis. This series underscores the pivotal role of PET/CT in distinguishing between true progression, treatment-related inflammatory changes, and emphasizes the need for physicians to be aware of these phenomena.

Source: Indian Journal of Nuclear Medicine

DOI: 10.25259/ijnm_83_25

Authors: Yeshwanth Edamadaka, Prathyusha Bikkina, Abubacker Zakir Ali

Institution: Basavatarakam Indo American Cancer Hospital and Research Institute

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7154152017