Work

Data from: Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations

Year: 2026

Type: dataset

Abstract: The data were generated from bone marrow immune cells of ovariectomized (OVX) C57BL/6 mice exposed to either filtered air (FA) or wood smoke (WS) to investigate how ovarian hormone deficiency modifies the immunotoxic effects of acute air pollution exposure. The dataset includes raw paired-end FASTQ files and filtered feature-barcode count matrices (.h5 format) for three biological replicates from each of the two experimental groups (OVX-FA and OVX-WS). Please note that other data presented in the manuscript, such as the ex vivo functional and metabolic assays on bone marrow-derived macrophages (BMDMs), are not included in this deposit. These data can be used to reproduce the transcriptomic analyses of bone marrow immune composition, cell-type-specific differential gene expression, and pathway enrichment results described in the manuscript.

Source: DRYAD

DOI: 10.5061/dryad.bvq83bknp

Authors: Oh, Mijung, Zychowski, Katherine

Institution: University of New Mexico

Language: English

Topic: Immunotoxicology and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Environmental Health Sciences