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Caregiver-Targeted Online Multicomponent Intervention and Quality of Life in Alzheimer’s Disease: A Randomized Controlled Trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Objectives To examine whether a brief, fully online caregiver-targeted multicomponent psychological intervention improves self-reported quality of life (QoL) in people with Alzheimer’s disease (AD).Methods In this randomized controlled trial, 56 people with AD and their informal caregivers were assigned to an intervention (n = 28) or usual-care control group (n = 28). Caregivers in the intervention group completed an 8-week online program combining psychoeducation and mindfulness. Outcomes were assessed at baseline and post-intervention by blinded assessors. The primary outcome was QoL assessed with the QoL-AD. Group-by-time effects were analyzed using linear mixed-effects models.Results Compared with controls, people with AD in the intervention group showed greater improvement in QoL-AD (p < .001). Neuropsychiatric symptoms worsened in the control group but remained stable in the intervention group (group × time p = .039). No significant effects were observed for cognitive performance.Conclusions A brief caregiver-targeted online intervention was associated with improved QoL and stabilization of neuropsychiatric symptoms in people with AD.Clinical implications Trial registration: ClinicalTrials.gov, NCT04280861 (registered 17 February 2020).

Source: Clinical Gerontologist

DOI: 10.1080/07317115.2026.2659355