Work

Targeted Modulation of YAP Signaling: Advancing Small-Molecule Strategies in Oncology and Tissue Regeneration

Year: 2026

Type: article

Abstract: The Hippo-YAP pathway has emerged as a central regulator of tissue growth and oncogenesis, yet remains resistant to conventional pharmacological targeting. Patent application WO 2026/044133 A1 discloses small-molecule strategies that modulate YAP activity through transcriptional complex disruption and protein stability interference. Robust cellular validation across YAP-dependent cancer models establishes proof of concept for tractable YAP inhibition, with implications spanning oncology and regenerative medicine.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00173

Authors: Anna C. Renner, Robert B. Kargbo

Institution: North Dakota State University

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7154254863

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Cites: 6

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