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Impact of Saline Instillation and Drainage on Oxygenation During Whole Lung Lavage

Year: 2026

Type: article

Abstract: ABSTRACT: Whole lung lavage (WLL) for pulmonary alveolar proteinosis, performed under one-lung ventilation (OLV), illustrates the dynamic interplay between alveolar expansion and pulmonary vascular responses. Instillation of warm saline into the nonventilated lung compresses pulmonary vessels, mimicking hypoxic pulmonary vasoconstriction and enhancing oxygenation. Conversely, drainage of the saline relieves vascular compression, worsens ventilation-perfusion (V/Q) mismatch, and leads to a decline in oxygenation. This cyclical pattern underscores the physiological shifts that influence oxygenation during WLL.

Source: Annals of Cardiac Anaesthesia

DOI: 10.4103/aca.aca_262_25

Authors: Dhananj Shivganesh, Krishna Prasad Gourav, Ritesh Agarwal, Sunder Negi, Bhupesh Kumar

Institution: Post Graduate Institute of Medical Education and Research

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7154291935

FWCI:

Cites: 3

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