Work

Overactive PDGFRα and PDGFRβ promote distinct phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving muscle growth

Year: 2026

Type: article

Abstract: This study demonstrates that overactive PDGFRα and PDGFRβ signaling drive distinct and sex-specific skeletal muscle remodeling phenotypes. Overactive PDGFRα induces robust fibrosis characterized by increased insoluble and cross-linked collagen, elevated LOX and AGE levels, and marked muscle stiffness. Thus, establishing a new model to study skeletal muscle fibrosis. Overactive PDGFRβ unexpectedly promoted skeletal muscle hypertrophy and reduced fat mass with minimal fibrosis, revealing a previously unrecognized role in regulating muscle growth in vivo.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00035.2026

Authors: Mariola Gimla, Szczepan Olszewski, Jacob L. Brown, Christiana J. Raymond-Pope, Sandra Rigsby, Frederick F. Peelor, Hae Ryong Kwon, Longbiao Yao, Lorin E. Olson, Jordan D. Fuqua, Benjamin F. Miller

Institutions: Oklahoma Medical Research Foundation, Florida State University, Oklahoma City VA Medical Center

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Biomedical Laboratory Research and Development, VA Office of Research and Development, National Institutes of Health, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1451118962, G156233380, G1899865448, PDGFRB Signaling in Progressive Skin Disease, G5177731442, G6205905650, G7218568665, G7961875653, Investigating TFEB as a critical node to improve proteostatic maintenance and skeletal muscle function with age

OpenAlex ID: W7154303513

FWCI:

Cites: 52

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